
Mitch A. Phelps, PhD
Mitch A. Phelps, PhD is Director of the OSU Comprehensive Cancer Center Pharmacoanalytical Shared Resource, which supports pharmacokinetic (PK)/pharmacodynamic (PD) study design and conduct for pre-clinical and clinical drug development. Dr. Phelps has directed PK/PD studies in preclinical disease models and in early phase clinical trials for nearly ten years. His research group focuses on development of small molecule and oligonucleotide anticancer and immune-modulatory agents here at OSU, using statistical modeling and simulation of PK/PD data to understand how genetic and other factors contribute to differences in therapy outcomes among individuals. Dr. Phelps is an associate professor in the College of Pharmacy Division of Pharmaceutics and Pharmaceutical Chemistry and in the College of Medicine Department of Pharmacology.
Research Interests
Preclinical Disease
Early Phase Clinical Trials
Development of Small Molecule and Oligonucleotide Anticancer and Immune Agents
Honors
- 2005 Outstanding Graduate Student Award.
- 2003-2004 Predoctoral Fellowship.
- 2004 Predoctoral Fellowship.
- 2003 Ray Travel Award.
- 2001 Hazel Brown Teaching Award.
Journal Articles
2020
- 2020, "Pharmacological prevention of neonatal opioid withdrawal in a pregnant guinea pig model." ,
2017
- 2017, "Overcoming Resistance to Anabolic Selective Androgen Receptor Modulator (SARM) Therapy in Experimental Cancer Cachexia with Histone Deacetylase Inhibitor AR-42." ,
- 2017, "Associations of High-Dose Melphalan Pharmacokinetics and Outcomes in the Setting of a Randomized Cryotherapy Trial." Clin Pharmacol Ther ePub ahead of print, ePub - ePub. ,
2016
- 2016, "NK Cell-Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines." Cancer Immunol Res 4, no. 4, 323-36 - 323-36. ,
- 2016, "Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers." J Proteomics 136, 89-98 - 89-98. ,
- 2016, "Preclinical Pharmacokinetics Study of R- and S-Enantiomers of the Histone Deacetylase Inhibitor, AR-42 (NSC 731438), in Rodents." AAPS J 18, no. 3, 737-45 - 737-45. ,
- 2016, "Non-immunosuppressive FTY720-derivative OSU-2S mediates reactive oxygen species-mediated cytotoxicity in canine B-cell lymphoma." Vet Comp Oncol ePub ahead of print, ePub - ePub. ,
- 2016, "Reproducibility Project: Cancer Biology; Reproducibility Project Cancer Biology. Registered report: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs." Elife 5, e12470 - e12470. ,
2015
- 2015, "Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia." Leukemia 29, no. 2, 346-55 - 346-55. ,
- 2015, "Phase I dose escalation trial of the novel proteasome inhibitor carfilzomib in patients with relapsed chronic lymphocytic leukemia and small lymphocytic lymphoma." Leuk Lymphoma 56, no. 10, 2834-40 - 2834-40. ,
- 2015, "OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells." Blood 125, no. 2, 284-95 - 284-95. ,
- 2015, "Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia." Blood 125, no. 17, 2689-92 - 2689-92. ,
- 2015, "Reduced occurrence of tumor flare with flavopiridol followed by combined flavopiridol and lenalidomide in patients with relapsed chronic lymphocytic leukemia (CLL)." Am J Hematol 90, no. 4, 327-33 - 327-33. ,
- 2015, "The combination of milatuzumab, a humanized anti-CD74 antibody, and veltuzumab, a humanized anti-CD20 antibody, demonstrates activity in patients with relapsed and refractory B-cell non-Hodgkin lymphoma." Br J Haematol 169, no. 5, 701-10 - 701-10. ,
- 2015, "ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo." Exp Hematol 43, no. 9, 770-4 - 770-4. ,
2014
- 2014, "A dose escalation feasibility study of lenalidomide for treatment of symptomatic, relapsed chronic lymphocytic leukemia." Leuk Res 38, no. 9, 1025-9 - 1025-9. ,
- 2014, "Comparison of high-dose intermittent and low-dose continuous oral artemisinin in dogs with naturally occurring tumors." J Am Anim Hosp Assoc 50, no. 6, 390-5 - 390-5. ,
- 2014, "Erlotinib in African Americans with advanced non-small cell lung cancer: a prospective randomized study with genetic and pharmacokinetic analyses." Clin Pharmacol Ther 96, no. 2, 182-91 - 182-91. ,
- 2014, "Establishing a clinical pharmacology fellowship program for physicians, pharmacists, and pharmacologists: a newly accredited interdisciplinary training program at the Ohio State University." Adv Med Educ Pract 5, 191-6 - 191-6. ,
- 2014, "Flavopiridol can be safely administered using a pharmacologically derived schedule and demonstrates activity in relapsed and refractory Non-Hodgkin's Lymphoma." Am J Hematol 89, no. 1, 19-24 - 19-24. ,
- 2014, "Liquid chromatography-tandem mass spectrometry assay for the simultaneous quantification of simvastatin, lovastatin, atorvastatin, and their major metabolites in human plasma." J Chromatogr B Analyt Technol Biomed Life Sci 983-4, 18-25 - 18-25. ,
- 2014, "A phase I trial of flavopiridol in relapsed multiple myeloma." Cancer Chemother Pharmacol 73, no. 2, 249-57 - 249-57. ,
2013
- 2013, "Cyclophosphamide, alvocidib (flavopiridol), and rituximab, a novel feasible chemoimmunotherapy regimen for patients with high-risk chronic lymphocytic leukemia." Leukemia Research 37, no. 10, 1195-9 - 1195-9. ,
- 2013, "Site specific discrete PEGylation of (124)I-labeled mCC49 Fab' fragments improves tumor MicroPET/CT imaging in mice." Bioconjug Chem 24, no. 11, 1945-54 - 1945-54. ,
- 2013, "Standard pentostatin dose reductions in renal insufficiency are not adequate: selected patients with steroid-refractory acute graft-versus-host disease.." Clinical Pharmacokinetics 52, no. 8, 705-12 - 705-12. ,
- 2013, "Sensitive liquid chromatography/mass spectrometry methods for quantification of pomalidomide in mouse plasma and brain tissue.." J Pharm Biomed Anal 88, no. 25, 262-8 - 262-8. ,
- 2013, "A phase I study of prolonged infusion of triapine in combination with fixed dose rate gemcitabine in patients with advanced solid tumors." Investigational New Drugs 31, no. 3, 685-695 - 685-695. ,
- 2013, "Milatuzumab-Conjugated Liposomes as Targeted Dexamethasone Carriers for Therapeutic Delivery in CD74(+) B-cell Malignancies." CLINICAL CANCER RESEARCH 19, no. 2, 347-356 - 347-356. ,
- 2013, "A Pharmacokinetic/Pharmacodynamic Model of Tumor Lysis Syndrome in Chronic Lymphocytic Leukemia Patients Treated with Flavopiridol." CLINICAL CANCER RESEARCH 19, no. 5, 1269-1280 - 1269-1280. ,
- 2013, "Pharmacokinetics and dose escalation of the heat shock protein inhibitor 17-allyamino-17-demethoxygeldanamycin in combination with bortezomib in relapsed or refractory acute myeloid leukemia." Leukemia and Lymphoma E-pub ahead of print, 01 - 01. ,
2012
- 2012, "Pharmacokinetics and Tissue Disposition of Lenalidomide in Mice." AAPS JOURNAL 14, no. 4, 872-882 - 872-882. ,
- 2012, "Program in Pharmacogenomics at the Ohio State University Medical Center." PHARMACOGENOMICS 13, no. 7, 751-756 - 751-756. ,
- 2012, "Structurally Modified Curcumin Analogs Inhibit STAT3 Phosphorylation and Promote Apoptosis of Human Renal Cell Carcinoma and Melanoma Cell Lines." PLOS ONE 7, no. 8, e40724 - e40724. ,
- 2012, "Development and validation of sensitive liquid chromatography/tandem mass spectrometry method for quantification of bendamustine in mouse brain tissue." JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 905, 141-144 - 141-144. ,
- 2012, "Influence of exercise on the distribution of technetium Tc 99m medronate following intra-articular injection in horses." Am J Vet Res 73, no. 3, 418-25 - 418-25. ,
- 2012, "Flavopiridol treatment of patients aged 70 or older with refractory or relapsed chronic lymphocytic leukemia is a feasible and active therapeutic approach." HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 97, no. 3, 423-427 - 423-427. ,
2011
- 2011, "Multi-Institutional Phase II Study of Selumetinib in Patients With Metastatic Biliary Cancers.." Journal Of Clinical Oncology: Official Journal Of The American Society Of Clinical Oncology 29, no. 17, 2357-2363 - 2357-2363. ,
- 2011, "Resistance to the Translation Initiation Inhibitor Silvestrol is Mediated by ABCB1/P-Glycoprotein Overexpression in Acute Lymphoblastic Leukemia Cells." AAPS Journal 13, no. 3, 357-364 - 357-364. ,
- 2011, "Characterization of silvestrol pharmacokinetics in mice using liquid chromatography–tandem mass spectrometry." AAPS Journal 13, no. 3, 347-356 - 347-356. ,
- 2011, "Low incidence of opportunistic infections with single agent flavopiridol for treatment of chronic lymphocytic leukemia." Blood ,
- 2011, "Phase I Trial of Lenalidomide and CCI‐779 in Patients with Relapsed Multiple Myeloma: Evidence for Lenalidomide-CCI-779 Interaction via P-Glycoprotein." Journal of Clinical Oncology 29, no. 25, 3427-3434 - 3427-3434. ,
- 2011, "Pharmacogenomic Testing: Relevance in Medical Practice." Cleveland Clinic Journal of Medicine 78, no. 4, 243-257 - 243-257. ,
- 2011, "Risk Factors for Tumor Lysis Syndrome in patients with Chronic Lymphocytic Leukemia Treated with the Cyclin Dependent Kinase Inhibitor, Flavopiridol." Leukemia 25, no. 9, 1444-1451 - 1444-1451. ,
2010
- 2010, "A dose-finding, pharmacokinetic and pharmacodynamic study of a novel schedule of flavopiridol in patients with advanced solid tumors." Investigational New Drugs 30, no. 2, 629-638 - 629-638. ,
- 2010, "Pharmacokinetics of oral ivabradine in cats." Journal of Veterinary Pharmacology and Therapeutics 34, no. 5, 469-475 - 469-475. ,
- 2010, "Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias.." Haematologica 95, no. 7, 1098-1105 - 1098-1105. ,
- 2010, "Dose escalation of lenalidomide in relapsed or refractory acute leukemias.." Journal Of Clinical Oncology: Official Journal Of The American Society Of Clinical Oncology 28, no. 33, 4919-4925 - 4919-4925. ,
- 2010, "Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.." Plos One 5, no. 11, e13792 - e13792. ,
2009
- 2009, "Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia.." Blood 113, no. 12, 2637-2645 - 2637-2645. ,
- 2009, "A novel liposomal formulation of." Int J Pharm 365, no. 1-2, 170-4 - 170-4. ,
- 2009, "A novel liposomal formulation of flavopiridol.." International Journal Of Pharmaceutics 365, no. 1-2, 170-174 - 170-174. ,
- 2009, "Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease.." Journal Of Clinical Oncology: Official Journal Of The American Society Of Clinical Oncology 27, no. 35, 6012-6018 - 6012-6018. ,
- 2009, "A phase I/II dose escalation study of apolizumab (Hu1D10) using a stepped-up dosing schedule in patients with chronic lymphocytic leukemia and acute leukemia.." Leukemia & Lymphoma 50, no. 12, 1958-1963 - 1958-1963. ,
2008
- 2008, "Development and validation of a sensitive liquid chromatography/mass spectrometry method for quantitation of flavopiridol in plasma enables accurate estimation of pharmacokinetic parameters with a clinically active dosing schedule." JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 868, no. 1-2, 110-115 - 110-115. ,
- 2008, "Development and validation of a highly sensitive liquid chromatography/mass spectrometry method for simultaneous quantification of lenalidomide and flavopiridol in human plasma.." Therapeutic Drug Monitoring 30, no. 5, 620 - 620. ,
- 2008, "Development and validation of a rapid and sensitive high-performance liquid chromatography-mass spectroscopy assay for determination of 17-(allylamino)-17-demethoxygeldanamycin and 17-(amino)-17-demethoxygeldanamycin in human plasma.." Journal Of Chromatography. B, Analytical Technologies In The Biomedical And Life Sciences 871, no. 1, 15-21 - 15-21. ,
2007
- 2007, "Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia." Blood 109, no. 2, 399-404 - 399-404. ,
- 2007, "Flavopiridol in Chronic Lymphocytic Leukemia." Clinical Leukemia 5, no. 1, 292-297 - 292-297. ,
2005
- 2005, "Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats." Endocrinology 146, no. 11, 4887-4897 - 4887-4897. ,
Unknown
- Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5." PlosONE , "