Joseph P Kitzmiller, MD, PhD, FCP

Associate Director of the Center for Pharmacogenomics and Director of the Clinical Pharmacology Fellowship, OSU College of Medicine
M.S. in Engineering, The Ohio State University
Ph.D in Engineering, The Ohio State University
M.D. in Clinical Pharmacology, The Ohio State University

Joseph P. Kitzmiller, MD, PhD, FCP is a board-certified clinical pharmacologist and physician with several years of experience implementing early-phase drug trials. Dr. Kitzmiller conducts basic, translational, and clinical pharmacology research, mostly focused on pharmacogenomics, personalized healthcare, and cardiology- and pain-related pharmacotherapies.  He is the principal investigator of an NIH-sponsored 10-year clinical trial investigating statin pharmacogenomics at the OSU Wexner Medical Center.  Dr. Kitzmiller is an assistant professor in the College of Medicine Department of Pharmacology and in the College of Engineering Department of Biomedical Engineering.  He is the Associate Director of the Center for Pharmacogenomics and Director of the Clinical Pharmacology Fellowship in the College of Medicine.

Areas of Expertise

Pharmacology

Internal Medicine

Pharmacogenomics

 

Research Interests

Clinical Pharmacology

Pharmacogenomics

Personalized Healthcare

Cardiology

Pain-Related Pharmacotherapies

Clinical Trial: Statin Pharmacogenomics

Honors

  • 20110901-20160701 Clinical and Translational Scholar Award in Pharmacogenomics and Personalized Medicine.
  • 20150301 Faculty Acheivement Award in Research.
  • 20140601 Faculty Research Award in Integrative Health and Wellness.
  • 20110801 Young Investigator Award.

Journal Articles

2016

  • Kitzmiller, J.P.; Mikulik, E.B.; Dauki, A.M.; Murkherjee, C. et al., 2016, "Pharmacogenomics of statins: Understanding susceptibility to adverse effects." Pharmacogenomics and Personalized Medicine 9, 97-106 - 97-106.
  • Sardo, C.L.; Kitzmiller, J.P.; Apseloff, G.; Harris, R.B. et al., 2016, "An Open-Label Randomized Crossover Trial of Lyophilized Black Raspberries on Postprandial Inflammation in Older Overweight Males: A Pilot Study." American Journal of Therapeutics 23, no. 1, e86-e91 - e86-e91.

2015

  • Kitzmiller, J.P.; Barnett, C.J.; Steiner, N.S.; Stoicea, N. et al., 2015, "Buprenorphine: Revisiting the efficacy of transdermal delivery system." Therapeutic Delivery 6, no. 4, 419-422 - 419-422.
  • Luzum, J.A.; Theusch, E.; Taylor, K.D.; Wang, A. et al., 2015, "Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations." Journal of Cardiovascular Pharmacology 66, no. 1, 80-85 - 80-85.
  • Wang,Jiang; Luzum,Jasmine,A; Phelps,Mitch,A; Kitzmiller,Joseph,P, 2015, "Liquid chromatography-tandem mass spectrometry assay for the simultaneous quantification of simvastatin, lovastatin, atorvastatin, and their major metabolites in human plasma." JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 983, 18-25 - 18-25.
  • Kitzmiller, J.P.; Luzum, J.A.; Isackson, P.J.; Ma, C. et al., 2015, "GATM Polymorphism Associated with the Risk for Statin-Induced Myopathy Does Not Replicate in Case-Control Analysis of 715 Dyslipidemic Individuals." CELL METABOLISM 21, no. 4,
  • Kitzmiller,Joseph,P; Barnett,Christopher,J; Steiner,Nathan,S; Stoicea,Nicoleta; Kamar,Nawal; Luzum,Jasmine,A; Mikulik,Eduard; Bergese,Sergio,D, 2015, "Buprenorphine: revisiting the efficacy of transdermal delivery system.." THERAPEUTIC DELIVERY 6, no. 4, 419-422 - 419-422.

2014

  • Kitzmiller, J.P.; Phelps, M.A.; Neidecker, M.V.; Apseloff, G., 2014, "Establishing a clinical pharmacology fellowship program for physicians, pharmacists, and pharmacologists: a newly accredited interdisciplinary training program at the Ohio State University.." Adv Med Educ Pract 5, 191-196 - 191-196.
  • Korbel, L.; George, M.; Kitzmiller, J., 2014, "Clinically relevant pharmacogenomic testing in pediatric practice.." Clin Pediatr (Phila) 53, no. 9, 831-838 - 831-838.
  • Kitzmiller, J.P.; Luzum, J.A.; Baldassarre, D.; Krauss, R.M. et al., 2014, "CYP3A4*22 and CYP3A5*3 are associated with increased levels of plasma simvastatin concentrations in the cholesterol and pharmacogenetics study cohort.." Pharmacogenet Genomics 24, no. 10, 486-491 - 486-491.
  • Talameh, J.A.; Kitzmiller, J.P., 2014, "Pharmacogenetics of Statin-Induced Myopathy: A Focused Review of the Clinical Translation of Pharmacokinetic Genetic Variants.." J Pharmacogenomics Pharmacoproteomics 5, no. 2,
  • Kitzmiller,Joseph,P; Phelps,Mitch,A; Neidecker,Marjorie,V; Apseloff,Glen, 2014, "Establishing a clinical pharmacology fellowship program for physicians, pharmacists, and pharmacologists: a newly accredited interdisciplinary training program at the Ohio State University.." ADVANCES IN MEDICAL EDUCATION AND PRACTICE 5, 191-196 - 191-196.
  • George M, Korbel L, Haasz M, Coronado A, Kitzmiller JP, 2014, "Managing Acute Asthma Exacerbations in Pediatric Patients: Should Peak Flow Measurements (PFM) or Pediatric Respiratory Assessment Measure (PRAM) Scores be used to Titrate Bronchodialtor Treatment?." ANN PEDIATR CHILD HEALTH 2, no. 2, 1015-1018 - 1015-1018.

2013

  • Kitzmiller, J.P.; Sullivan, D.M.; Phelps, M.A.; Wang, D. et al., 2013, "CYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control." Drug Metabolism and Drug Interactions 28, no. 1, 59-63 - 59-63.
  • Kapil, R.P.; Cipriano, A.; Friedman, K.; Michels, G. et al., 2013, "Once-weekly transdermal buprenorphine application results in sustained and consistent steady-state plasma levels." Journal of Pain and Symptom Management 46, no. 1, 65-75 - 65-75.
  • George, M.; Haasz, M.; Coronado, A.; Salhanick, S. et al., 2013, "Acute dyskinesia, myoclonus, and akathisa in an adolescent male abusing quetiapine via nasal insufflation: A case study." BMC Pediatrics 13, no. 1,
  • Baldassarre, D.; Amato, M.; Frigerio, B.; Columbo, G. et al., 2013, "[Pharmacogenomic Biomarkers for the Prediction of Statin Efficacy and Safety].." G Ital Arterioscler 4, no. 4, 23-35 - 23-35.
  • Kitzmiller, J.P.; Foraker, R.E.; Rose, K.M., 2013, "Lipid-lowering pharmacotherapy and socioeconomic status: Atherosclerosis risk in communities (ARIC) surveillance study." BMC Public Health 13, no. 1,
  • Kitzmiller,Joseph,P; Binkley,Philip,F; Pandey,Saurabh,R; Suhy,Adam,M; Baldassarre,Damiano; Hartmann,Katherine, 2013, "Statin Pharmacogenomics: Pursuing Biomarkers for Predicting Clinical Outcomes." DISCOVERY MEDICINE 86, 45-51 - 45-51.
  • Apseloff, G.; Kitzmiller, J.P.; Tishler, C.L., 2013, "Credibility and comprehension of healthy volunteers in lengthy inpatient drug studies." American Journal of Therapeutics 20, no. 3, 257-260 - 257-260.

2012

  • George, M.; Kitzmiller, J.P.; Ewald, M.B.; O'Donell, K.A. et al., 2012, "Methadone Toxicity and Possible Induction and Enhanced Elimination in a Premature Neonate." Journal of Medical Toxicology 8, no. 4, 432-435 - 432-435.
  • George, M.; Phelps, M.A.; Kitzmiller, J.P., 2012, "Acetaminophen pediatric dose selection: Caregiver satisfaction regarding the antipyretic efficacy of acetaminophen in children." Clinical Pediatrics 51, no. 11, 1030-1031 - 1030-1031.
  • Kitzmiller, J.P.; Embi, P.J.; Manickam, K.; Sweet, K.M. et al., 2012, "Institutional profile: Program in pharmacogenomics at the ohio state university medical Center." Pharmacogenomics 13, no. 7, 751-756 - 751-756.

2011

  • Kitzmiller, J.P.; Groen, D.K.; Phelps, M.A.; Sadee, W., 2011, "Pharmacogenomic testing: Relevance in medical practice: Why drugs work in some patients but not in others." Cleveland Clinic Journal of Medicine 78, no. 4, 243-257 - 243-257.

2010

  • Kitzmiller, J.P.; Groen, D.K.; Ardeleanu, M.; Apseloff, G., 2010, "A novel minimally-invasive method for eliciting incisional pain in healthy adults." Journal of Anaesthesiology Clinical Pharmacology 26, no. 1, 54-58 - 54-58.

2009

  • Kitzmiller, J.P.; Groen, D.K.; Apseloff, G., 2009, "PI-34: An Analysis of Subjects in Clinical Trials Who, After Dosing, Report Predose Adverse Events and Abnormalities in Their Medical Histories (vol 85, pg S9, 2009)." CLINICAL PHARMACOLOGY & THERAPEUTICS 85, no. 5, 558-558 - 558-558.

2007

  • Kitzmiller, J.P.; Hansford, D.J.; Fortin, L.D.; Obrietan, K.H. et al., 2007, "Micro-field evoked potentials recorded from the porcine sub-dural cortical surface utilizing a microelectrode array." Journal of Neuroscience Methods 162, no. 1-2, 155-161 - 155-161.

2006

  • Kitzmiller,J; Beversdorf,D; Hansford,D, 2006, "Fabrication and testing of microelectrodes for small-field cortical surface recordings." BIOMEDICAL MICRODEVICES 8, no. 1, 81-85 - 81-85.