Joseph P Kitzmiller, MD, PhD, FCP

Associate Director of the Center for Pharmacogenomics and Director of the Clinical Pharmacology Fellowship, OSU College of Medicine
M.S. in Engineering, The Ohio State University
Ph.D in Engineering, The Ohio State University
M.D. in Clinical Pharmacology, The Ohio State University

Joseph P. Kitzmiller, MD, PhD, FCP is a board-certified clinical pharmacologist and physician with several years of experience implementing early-phase drug trials. Dr. Kitzmiller conducts basic, translational, and clinical pharmacology research, mostly focused on pharmacogenomics, personalized healthcare, and cardiology- and pain-related pharmacotherapies.  He is the principal investigator of an NIH-sponsored 10-year clinical trial investigating statin pharmacogenomics at the OSU Wexner Medical Center.  Dr. Kitzmiller is an assistant professor in the College of Medicine Department of Pharmacology and in the College of Engineering Department of Biomedical Engineering.  He is the Associate Director of the Center for Pharmacogenomics and Director of the Clinical Pharmacology Fellowship in the College of Medicine.

Areas of Expertise

Pharmacology

Internal Medicine

Pharmacogenomics

 

Research Interests

Clinical Pharmacology

Pharmacogenomics

Personalized Healthcare

Cardiology

Pain-Related Pharmacotherapies

Clinical Trial: Statin Pharmacogenomics

Honors

  • 2011-2016 Clinical and Translational Scholar Award in Pharmacogenomics and Personalized Medicine. .
  • 2015 Faculty Acheivement Award in Research. .
  • 2014 Faculty Research Award in Integrative Health and Wellness. .
  • 2011 Young Investigator Award. .

Journal Articles

2016

  • Kitzmiller JP, Mikulik EB, Dauki AM, Mukherjee C, Luzum JA, 2016, "Pharmacogenomics of statins: understanding susceptibility to adverse effects." PHARMACOGENOMICS AND PERSONALIZED MEDICINE 9, 97 - 106.
  • Sardo,Christine,L; Kitzmiller,Joseph,P; Apseloff,Glen; Harris,Robin,B; Roe,Denise,J; Stoner,Gary,D; Jacobs,Elizabeth,T, 2016, "An Open-Label Randomized Crossover Trial of Lyophilized Black Raspberries on Postprandial Inflammation in Older Overweight Males: A Pilot Study." AMERICAN JOURNAL OF THERAPEUTICS 23, no. 1, E86 - E91.
  • Kitzmiller JP, Luzum JA, Daukia A, Krauss RM, Medina MW, 2016, "Candidate-gene study of functional polymorphisms in SLCO1B1 and CYP3A4/5 and the cholesterollowering response to simvastatin." CLINICAL AND TRANSLATIONAL SCIENCE On line, Ahead of Print -

2015

  • Wang,Jiang; Luzum,Jasmine,A; Phelps,Mitch,A; Kitzmiller,Joseph,P, 2015, "Liquid chromatography-tandem mass spectrometry assay for the simultaneous quantification of simvastatin, lovastatin, atorvastatin, and their major metabolites in human plasma.." Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 983-984, 18 - 25.
  • Kitzmiller,Joseph,P; Barnett,Christopher,J; Steiner,Nathan,S; Stoicea,Nicoleta; Kamar,Nawal; Luzum,Jasmine,A; Mikulik,Eduard; Bergese,Sergio,D, 2015, "Buprenorphine: revisiting the efficacy of transdermal delivery system.." THERAPEUTIC DELIVERY 6, no. 4, 419 - 422.
  • Luzum,Jasmine,A; Theusch,Elizabeth; Taylor,Kent,D; Wang,Ann; Sadee,Wolfgang; Binkley,Philip,F; Krauss,Ronald,M; Medina,Marisa,W; Kitzmiller,Joseph,P, 2015, "Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations." JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 66, no. 1, 80 - 85.
  • Wang,Jiang; Luzum,Jasmine,A; Phelps,Mitch,A; Kitzmiller,Joseph,P, 2015, "Liquid chromatography-tandem mass spectrometry assay for the simultaneous quantification of simvastatin, lovastatin, atorvastatin, and their major metabolites in human plasma." JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 983, 18 - 25.
  • Kitzmiller,Joseph,P; Luzum,Jasmine,A; Isackson,Paul,J; Ma,Changxing; Medina,Marisa,W; Dauki,Anees,M; Mikulik,Eduard,B; Ochs-Balcom,Heather,M; Vladutiu,Georgirene,D, 2015, "GATM Polymorphism Associated with the Risk for Statin-Induced Myopathy Does Not Replicate in Case-Control Analysis of 715 Dyslipidemic Individuals." CELL METABOLISM 21, no. 4, 622 - 627.
  • Wang,Jiang; Luzum,Jasmine,A; Phelps,Mitch,A; Kitzmiller,Joseph,P, 2015, "Liquid chromatography-tandem mass spectrometry assay for the simultaneous quantification of simvastatin, lovastatin, atorvastatin, and their major metabolites in human plasma.." Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 983-984, 18 - 25.

2014

  • Kitzmiller,Joseph,P; Luzum,Jasmine,A; Baldassarre,Damiano; Krauss,Ronald,M; Medina,Marisa,W, 2014, "CYP3A4*22 and CYP3A5*3 are associated with increased levels of plasma simvastatin concentrations in the cholesterol and pharmacogenetics study cohort." PHARMACOGENETICS AND GENOMICS 24, no. 10, 486 - 491.
  • Talameh JA, Kitzmiller JP, 2014, "Pharmacogenetics of Statin-Induced Myopathy: A Focused Review of the Clinical Translation of Pharmacokinetic Genetic Variants." J PHARMACOGENOMICS PHARMACOPROTEOMICS 5, no. 2, 128 -
  • George M, Korbel L, Haasz M, Coronado A, Kitzmiller JP, 2014, "Managing Acute Asthma Exacerbations in Pediatric Patients: Should Peak Flow Measurements (PFM) or Pediatric Respiratory Assessment Measure (PRAM) Scores be used to Titrate Bronchodialtor Treatment?." ANN PEDIATR CHILD HEALTH 2, no. 2, 1015 - 1018.
  • Korbel,Lindsey; George,Mathew; Kitzmiller,Joseph, 2014, "Clinically Relevant Pharmacogenomic Testing in Pediatric Practice." CLINICAL PEDIATRICS 53, no. 9, 831 - 838.
  • Kitzmiller,Joseph,P; Phelps,Mitch,A; Neidecker,Marjorie,V; Apseloff,Glen, 2014, "Establishing a clinical pharmacology fellowship program for physicians, pharmacists, and pharmacologists: a newly accredited interdisciplinary training program at the Ohio State University.." ADVANCES IN MEDICAL EDUCATION AND PRACTICE 5, 191 - 196.

2013

  • Kitzmiller JP, Sullivan DM, Phelps MA, Wang D, Sadee W, 2013, ". CYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control." DRUG METABOLISM AND DRUG INTERACTIONS On line, Ahead of Print -
  • Kitzmiller,Joseph,P; Foraker,Randi,E; Rose,Kathy,M, 2013, "Lipid-lowering pharmacotherapy and socioeconomic status: atherosclerosis risk in communities (ARIC) surveillance study." BMC PUBLIC HEALTH 13, 488 -
  • George,Mathew; Haasz,Maya; Coronado,Alvaro; Salhanick,Steven; Korbel,Lindsey; Kitzmiller,Joseph,P, 2013, "Acute dyskinesia, myoclonus, and akathisa in an adolescent male abusing quetiapine via nasal insufflation: a case study." BMC PEDIATRICS 13, 187 -
  • Baldassarre D, Amato M, Frigerio B, Columbo G, Binkley PF, Pandey SR, Suhy AM, Hartmann K, Kitzmiller JP, 2013, "Pharmacogenomic Biomarkers for the Prediction of Statin Efficacy and Safety." G ITAL ARTERIOSCLER 4, no. 4, 23 - 35.
  • Kitzmiller,Joseph,P; Binkley,Philip,F; Pandey,Saurabh,R; Suhy,Adam,M; Baldassarre,Damiano; Hartmann,Katherine, 2013, "Statin pharmacogenomics: pursuing biomarkers for predicting clinical outcomes.." Discovery medicine 16, no. 86, 45 - 51.
  • Apseloff,Glen; Kitzmiller,Joseph,P; Tishler,Carl,L, 2013, "Credibility and Comprehension of Healthy Volunteers in Lengthy Inpatient Drug Studies." AMERICAN JOURNAL OF THERAPEUTICS 20, no. 3, 257 - 260.
  • Kitzmiller,Joseph,P; Binkley,Philip,F; Pandey,Saurabh,R; Suhy,Adam,M; Baldassarre,Damiano; Hartmann,Katherine, 2013, "Statin Pharmacogenomics: Pursuing Biomarkers for Predicting Clinical Outcomes." DISCOVERY MEDICINE 86, 45 - 51.
  • Kitzmiller,Joseph,P; Binkley,Philip,F; Pandey,Saurabh,R; Suhy,Adam,M; Baldassarre,Damiano; Hartmann,Katherine, 2013, "Statin pharmacogenomics: pursuing biomarkers for predicting clinical outcomes.." Discovery medicine 16, no. 86, 45 - 51.
  • Kitzmiller,Joseph,P; Binkley,Philip,F; Pandey,Saurabh,R; Suhy,Adam,M; Baldassarre,Damiano; Hartmann,Katherine, 2013, "Statin pharmacogenomics: pursuing biomarkers for predicting clinical outcomes.." Discovery medicine 16, no. 86, 45 - 51.

2012

  • Kitzmiller JP, Embi PJ, Manickam K, Sweet KM, Phelps MA, Jackson RD, Marsh CB, Sadee W, 2012, "Program in Pharmacogenomics at the Ohio State University Medical Center." PHARMACOGENOMICS 13, no. 7, 751 - 756.
  • George M, Phelps MA, Kitzmiller JP, 2012, "Acetaminophen Pediatric Dose Selection: Caregiver Satisfaction Regarding the Antipyretic Efficacy of Acetaminophen in Children." CLINICAL PEDIATRICS 51, no. 11, 1030 - 1031.
  • George,Mathew; Phelps,Mitch,A; Kitzmiller,Joseph,P, 2012, "Acetaminophen pediatric dose selection: caregiver satisfaction regarding the antipyretic efficacy of acetaminophen in children.." Clinical pediatrics 51, no. 11, 1030 - 1031.
  • Kapil RP, Cipriano A, Friedman K, Michels G, Shet MS, Colucci SV, Apseloff G, Kitzmiller JP, Harris SC, 2012, "Once-Weekly Transdermal Buprenorphine Application Results in Sustained and Consistent Steady-State Plasma Levels." JOURNAL OF PAIN SYMPTOM MANAGEMENT On Line, Ahead of Print -
  • Apseloff G, Kitzmiller JP, Tischler CL, 2012, ". Credibility and Comprehension of Healthy Volunteers in Lengthy Inpatient Drug Studies." AMERICAN JOURNAL OF THERAPEUTICS On Line, Ahead of Print -
  • George M, Kitzmiller JP, Ewald MB, O’Donell KA, Becter ML, Salhanick S, 2012, "Methadone Toxicity and Possible Induction and Enhanced Elimination in a Premature Neonate." JOURNAL OF MEDICAL TOXICOLOGY 8, no. 4, 432 - 5.

2011

  • Kitzmiller JP, Groen DK, Phelps MA, Sadee W, 2011, "Pharmacogenomic testing: Relevance in medical practice Why drugs work in some patients but not in others." CLEVELAND CLINIC JOURNAL OF MEDICINE 78, no. 4, 243 - 257.

2010

  • Kitzmiller JP, Groen DK, Ardeleanu M, Apseloff G., 2010, "A Novel Minimally-Invasive Method for Eliciting Incisional Pain in Healthy Adults.." JOURNAL OF ANESTHESIOLOGY AND CLINICAL PHARMACOLOGY 26, 54 - 58..

2009

  • Kitzmiller,J,P, 2009, "AN ANALYSIS OF SUBJECTS IN CLINICAL TRIALS WHO, AFTER DOSING, REPORT PREDOSE ADVERSE EVENTS AND ABNORMALITIES IN THEIR MEDICAL HISTORIES." CLINICAL PHARMACOLOGY & THERAPEUTICS 85, S19 - S19.

2007

  • Kitzmiller JP, Hansford DJ, Fortin LD, Obrietan KH, Bergdall VK, Beversdorf DQ, 2007, "Micro-field evoked potentials recorded from the porcine sub-dural cortical surface utilizing a microelectrode array." JOURNAL OF NEUROSCIENCE METHODS 162, no. 1-2, 155 - 161.

2006

  • Kitzmiller,J; Beversdorf,D; Hansford,D, 2006, "Fabrication and testing of microelectrodes for small-field cortical surface recordings." BIOMEDICAL MICRODEVICES 8, no. 1, 81 - 85.

Unknown

  • Kitzmiller JP, Luzum JA, Dauki A, Krauss RM, Medina MW, "Candidate-gene study of functional polymorphisms in SLCO1B1 and CYP3A4/5 and the cholesterol-lowering response to simvastatin." CLIN TRANS SCI