Frederick Villamena, PhD

Associate Professor, College of Medicine, Dept. of Biological Chemistry and Pharmacology

Honors

  • 2011 Outstanding Thomasian Chemistry Alumni Awardee. .
  • 2009 Visiting Professor. .
  • 2007 Visiting Professor. .
  • 2001-2003 Ruth L. Kirschtein Institutional National Service Award Post Doctoral Fellowship. .
  • 2002 Young Investigator Award 7th International Spin Trapping Meeting. .
  • 2000-2001 CNRS Post Doctoral Fellow. .
  • 1998-2000 ORISE Post Doctoral Fellow. .

Book Chapters

2003

  • Jay L. Zweier and Frederick A. Villamena. 2003. "Chemistry of Free Radicals in Biological Systems." In Oxidative Stress and Cardiac Failure,

Journal Articles

2011

  • 2011, "Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways.." Vascul Pharmacol 55, no. 1-3,

2010

  • 2010, "Synthesis, physical-chemical and biological properties of amphiphilic amino acid conjugates of nitroxides." NEW JOURNAL OF CHEMISTRY 34, no. 9,
  • 2010, "Synthesis of N-14- and N-15-labeled Trityl-nitroxide Bradicals with Strong Spin-Spin Interaction and Improved Sensitivity to Redox Status and Oxygen." JOURNAL OF ORGANIC CHEMISTRY 75, no. 22,
  • 2010, "Lipoic acid effects on established atherosclerosis." LIFE SCIENCES 86, no. 3-4,

2009

  • 2009, "The Radical Trap 5,5-Dimethyl-1-Pyrroline N-Oxide Exerts Dose-Dependent Protection against Myocardial Ischemia-Reperfusion Injury through Preservation of Mitochondrial Electron Transport." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 329, no. 2,

2008

  • 2008, "Inactivation of mitochondrial respiratory chain complex I leads mitochondrial nitric oxide synthase to become pro-oxidative." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 367, no. 4,
  • Kutala, V. K.; Villamena, F. A.; Ilangovan, G.; Maspoch, D.; Roques, N.; Veciana, J.; Rovira, C. and Kuppusamy, P, 2008, "Reactivity of Superoxide Anion Radical with a Perchlorotriphenylmethyl (Trityl) Radical.." J. Phys. Chem. B 112, 158-167 - 158-167.

2007

  • 2007, "Synthesis and spin trapping properties of a new spirolactonyl-nitrone." FREE RADICAL BIOLOGY AND MEDICINE 43,
  • 2007, "Synthesis and characterization of a perchlorotriphenylmethyl (trityl) triester radical: A potential sensor for superoxide and oxygen in biological systems." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17, no. 14,
  • Villamena FA,* Xia S, Merle JK, Lauricella R, Tuccio B, Hadad CM, Zweier JL, 2007, "Role of Intramolecular H-Bond and Electrostatics on the Reactivity of Superoxide Radical Anion with Cyclic Nitrones.." J Am Chem Soc 129, 8177-8191 - 8177-8191.
  • 2007, "Theoretical and experimental studies of the spin trapping of inorganic radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. Carbonate radical anion." JOURNAL OF PHYSICAL CHEMISTRY A 111, no. 2,
  • Lu, D.; Villamena, FA*; Zhang, G; Nadas, J; Zweier, JL; Johnson, W; Cardounel, AJ; Wang PG, 2007, "Caged RSNOs: The Next Generation of S-Nitrosothiols.." J Am Chem Soc 129, 5503-5514 - 5503-5514.
  • 2007, "Large-scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17, no. 24,
  • 2007, "Rate constants of hydroperoxyl radical addition to cyclic nitrones: A DFT study." JOURNAL OF PHYSICAL CHEMISTRY A 111, no. 39,

2006

  • 2006, "Theoretical and experimental studies of the spin trapping of inorganic radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 1. Carbon dioxide radical anion." JOURNAL OF PHYSICAL CHEMISTRY A 110, no. 49,
  • 2006, "Reactivity of molecular oxygen with ethoxycarbonyl derivatives of tetrathiatriarylmethyl radicals." JOURNAL OF ORGANIC CHEMISTRY 71, no. 19,

2005

  • Villamena, F. A.*; Hadad, C. M.; Zweier, J. L, 2005, "Comparative DFT Study of the Spin Trapping of Methyl, Mercapto, Hydroperoxy, Superoxide, and Nitric Oxide Radicals by Various Substituted Cyclic Nitrones.." J. of Phys. Chem. A 109, 1662-1674 - 1662-1674.
  • Locigno, E. J.; Zweier, J. L.; Villamena, F. A.*, 2005, "Nitric Oxide Release from the Unimolecular Decomposition of the Superoxide Radical Anion Adduct of Cyclic Nitrones in Aqueous Medium." Org. Biomol. Chem 3, 3220-3227 - 3220-3227.
  • 2005, "Cancer chemopreventive oltipraz generates superoxide anion radical." ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 435, no. 1,
  • 2005, "Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. The thermodynamics of decay and EPR spectral properties." JOURNAL OF PHYSICAL CHEMISTRY A 109, no. 27,
  • 2005, "Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 1. The thermodynamics of formation and its acidity." JOURNAL OF PHYSICAL CHEMISTRY A 109, no. 27,
  • 2005, "Comparative DFT study of the spin trapping of methyl, mercapto, hydroperoxy, superoxide, and nitric oxide radicals by various substituted cyclic nitrones." JOURNAL OF PHYSICAL CHEMISTRY A 109, no. 8,

2004

  • 2004, "Spin trapping by 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO): Theoretical and experimental studies." JOURNAL OF ORGANIC CHEMISTRY 69, no. 23,
  • 2004, "Theoretical study of the spin trapping of hydroxyl radical by cyclic nitrones: A density functional theory approach." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 126, no. 6,

2003

  • 2003, "Kinetic study and theoretical analysis of hydroxyl radical trapping and spin adduct decay of alkoxycarbonyl and dialkoxyphosphoryl nitrones in aqueous media." JOURNAL OF PHYSICAL CHEMISTRY A 107, no. 22,
  • 2003, "Cyclic voltammetry of metal complexes of nitrones and nitroxides." INORGANICA CHIMICA ACTA 342,

2002

  • Villamena, F.; Zweier, J, 2002, "Superoxide Radical Trapping and Spin Adduct Decay of 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-oxide (BocMPO): Kinetics and Theoretical Analysis.." J. Chem. Soc., Perkin Trans. 2, 1340-1344 - 1340-1344.
  • Methachit, N.; McGrath C.; Stewart, J.; Blans, P.; Villamena, F.; Zweier, J.; Fishbein, J. C, 2002, "Thiolytic Chemistry of Alternative Precursors to the Major Metabolite of the Cancer Chemopreventive Oltipraz.." J. Org. Chem. 67, 9406-9413 - 9406-9413.

2001

  • 2001, "Caffeine selectivity of divinylbenzene crosslinked polymers in aqueous media." JOURNAL OF APPLIED POLYMER SCIENCE 82, no. 1,

1998

  • Dickman, M.; Ward, J.; Villamena, F.; Crist, D, 1998, "Bis(?-(N-[(methylthio)phenylmethylene] methanamine-N-oxide-O)bis(1,1,1,5,5,5-hexafluoropentane-2,4 -dionato-O,O')nickel(II)).." Acta Crystallogr C54, 929-930 - 929-930.
  • 1998, "Stabilization of a nitroxide with a beta-hydrogen by metals: Structure and magnetic properties of adducts of N-oxy-N-tert-butyl-(2-pyridyl)phenylmethanamine with Mn(II), Ni(II), and Co(II) hexafluoroacetylacetonates." INORGANIC CHEMISTRY 37, no. 7,
  • 1998, "Nitrones as ligands in complexes of Cu(II), Mn(II), Co(II), Ni(II), Fe(II), and Fe(III) with N-tert-butyl-alpha-(2-pyridyl)nitrone and 2,5,5-trimethyl-1-pyrroline-N-oxide." INORGANIC CHEMISTRY 37, no. 7,
  • Villamena, F.; Crist, D, 1998, "Metal-Nitrone Complexes: Spin Trapping and Solution Characterization.." J. Chem. Soc., Dalton Trans. 23, 4055-4062 - 4055-4062.